S11E9 - Michelle L. Johnson – Altering Traits and Fates of Wild Populations with Allele Sails

Altering Traits and Fates of Wild Populations with Mendelian DNA Modifying Allele Sails: Possible Contexts and Modeling Considerations

Zoom Only | How can we use genetics to manage wild populations, and how do the bioengineers working on these projects predict their impact?

• Download seminar flyer
• Johnson, M.L., Hay, B.A. & Maselko, M. Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails. Nat Commun 15, 6665 (2024).

Michelle Johnson

Research Technician at Caltech | LinkedIn Michelle Johnson (he/him) is a research technician working with Dr. Bruce Hay at Caltech. The lab is interested in using genetic technologies to control the composition and fate of wild populations. Specifically, they work on designing and characterizing novel gene drive systems in different species. Michelle is a computational biologist and spends most of his time designing models, writing software, and describing the effect of novel gene drive systems on various populations. He is especially interested in how the inclusion and exclusion of certain model features can impact results. Michelle graduated from Harvey Mudd College with a BS in Mathematical & Computational Biology in 2023 and has worked with Bruce Hay since then.

Abstract

Population-scale genome modification can alter the composition or fate of wild populations. Synthetic gene drives provide one set of tools, but their use is complicated by scientific, regulatory, and social issues associated with transgene persistence and flow. We have proposed an alternative approach, called an Allele Sail. It consists of a genome editor (the Wind), which is inherited in a Mendelian fashion. This editor introduces DNA sequence edits (the Sail), which experiences an arithmetic, Super-Mendelian increase in frequency. Through modeling, we demonstrate this system’s ability to bring about both population modification and suppression. A relatively simple system, Allele Sails may prove useful since the spread and persistence of the transgenic component can be limited. We outline contexts where Allele Sails could be useful and briefly discuss the modeling field and perspectives on modeling for risk assessment.

---

The Genetic Engineering and Society (GES) Colloquium is a seminar series that brings in speakers to present and stimulate discussion on a variety of topics related to existing and proposed biotechnologies and their place within broader societal changes. GES Colloquium is jointly taught by Drs. Katie Barnhill and Nourou Barry, and we’re featuring a mostly student-led seminar series. Students will be taking the lead in identifying, inviting, and hosting most of the speakers, providing a great opportunity for them to build their networks and grow as professionals. To support their efforts, we encourage you to join our in-person seminars, which will now take place in Withers 331. Your presence makes a big difference in creating a supportive environment for our students. Remember, we regularly post colloquium seminars as videos on Panopto and on our GES Lectures podcast, allowing you to revisit or catch up on these recordings at your convenience. Please subscribe to the GES newsletter and LinkedIn for updates.

Genetic Engineering and Society Center Colloquium Home | Zoom Registration | Watch Colloquium Videos | LinkedIn | Newsletter

GES Center at NC State University—Integrating scientific knowledge & diverse public values in shaping the futures of biotechnology.

Find out more at https://ges-center-lectures-ncsu.pinecast.co